Alzheimer's disease, the most common dementia, has long been thought by researchers to completely erase the memory of patients, but a new study found recently that memory loss in people with Alzheimer's may actually be recovered Come because the disease may not ruin all memory as it had been before. The study was conducted by a research team at Columbia University. The research team, which conducted the study on rats, found that memory was not completely erased by the disease Alzheimer's, but simply made memory harder to extract. New data also show that these "lost" memories may be re-awakened by manually activating the neurons in the storage area. Alzheimer's disease is a degenerative brain disease that develops, usually in the elderly, and is believed to damage memory and other underlying cognitive functions. One of the most striking features of this disease is the mass of protein known as "beta-amyloid", which is thought to damage and destroy the patient's brain cells. The researchers found that by stimulating the area of ​​the rat brain that is associated with memory storage, they were able to awaken memory lost by the mouse. The team studied two groups of mice, one group was healthy and the other group had a disease equivalent to human Alzheimer's disease. The researchers genetically engineered these mice to make their neurons emit yellow light when memory storage is activated and red when memory waking is activated. The researchers then performed two tests on the memory of these mice, the first to let the mice smell the lemon and then shock them. After a week, letting them smell lemon flavors again would trigger a pause in healthy mice, but the sick mice did not respond. This shows that mice with similar human Alzheimer's disease do not remember the strong association between lemon flavor and electric shock. Researchers looked at the mouse brain scan during the test and found that the hippocampus in the brain area where the memory was recorded showed a signal that explains how the mouse behaves. In non-diseased mice, researchers see yellow and red light overlapping, meaning they are extracting stored shock memories at the same location. But in diseased mice, different cells glow red during recall, suggesting they might get the wrong memory. Lead researcher Christine Dunney said the results explain why dementia patients sometimes have the wrong memories. Mouse experiments may indicate that one may send signals to the wrong brain cells. After the first round of testing, the team used a genetically modified technique called "optogenetics" to reactivate mice 'memory of shocks. The technique is operated by shining a blue optical fiber cable into the brain to stimulate memory storage neurons, causing the mouse to suspend again when it smelled lemon. This suggests that memories previously thought to have been lost may still exist in the brain and may be restored. However, at present, optogenetics can not yet be applied to humans because it is unsafe to use lasers for neurons or brain cells. Dr. Denney pointed out that with this research as a foundation, it is expected to develop drugs or technologies that stimulate the memory of the brain in the future to help people with Alzheimer's disease. Industrial Application Software Integrated management and control system for beneficiation has solved the integration problem between production and resource management < management > and the automatic control of production lines. Integrated Control System,Enterprise Control System,Management And Control System,Industrial Monitoring System Dandong Dongfang Measurement & Control Technology Co., Ltd. , https://www.dfmc-tec.com
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